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Sera from anti-Jo-1-positive patients with polymyositis and interstitial lung disease induce expression of intercellular adhesion molecule 1 in human lung endothelial cells
Arthritis & Rheumatism, 08/10/09

Helmers SB et al. – EC activation with ICAM–1 expression could contribute to the multiorgan involvement, including the development of myositis and ILD, in patients carrying anti–Jo–1 autoantibodies. The EC–activating factors are not the autoantibodies themselves, but might be systemic factors associated with these autoantibodies.

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