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The role of neutrophil apoptosis in juvenile-onset systemic lupus erythematosus
Arthritis & Rheumatism, 08/05/09

Midgley A et al. – The data demonstrate an imbalance in proapoptotic and antiapoptotic factors in both neutrophils and sera from patients with juvenile–onset SLE. This imbalance results in increased neutrophil apoptosis in these patients. Correlations with markers of disease activity indicate that altered neutrophil apoptosis in juvenile–onset SLE patients may play a pathogenic role in this condition.

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