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See Latest ArticlesMethotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation
Arthritis & Rheumatism, 08/06/09
Baggott JE et al. – The findings of a non–normal distribution of 7–OH–MTX excretion suggest that there are at least 2 phenotypes for this catabolism. Decreased 7–OH–MTX formation suggests folic acid inhibition of AO and a better clinical response, while increased 7–OH–MTX formation may interfere with MTX polyglutamylation and binding to enzymes and, therefore, may increase MTX excretion and decrease MTX retention and efficacy in vivo.
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Today in Clinical Pharmacology...keeping you current
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A review of the effect of anticonvulsant medications on bone mineral density and fracture risk
The American Journal of Geriatric Pharmacotherapy, 03/19/10
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Today in Rheumatoid Arthritis...keeping you current
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Rheumatoid arthritis and autoimmune hemolysis: B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease
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Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA
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Risk factor profiles for atherosclerotic cardiovascular disease in Black and other Africans with established rheumatoid arthritis
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