Rheumatology Medical News about MIF, Systemic vasculitis, Polyangiitis

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Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis
Open Access Rheumatology: Research and Reviews, 08/11/09

Kanemitsu H et al. – Findings suggest that migration inhibitory factor (MIF) may have an important role in small vessel vasculopathy and serve as a useful serologic marker of Microscopic polyangiitis (MPA) disease activity.

Methods

Study investigates if MIF is involved in the disease activity of systemic vasculitis
Pts were divided into 3 groups based on the size of the affected vessels
MPA was considered as:
- Small vessel vasculitis (SVV)
- Polyarteritis nodosa as medium-sized vessel vasculitis (MVV), and
- Giant cell arteritis and Takayasu arteritis as large vessel vasculitis (LVV)
Sera from pts with systemic vasculitis and healthy individuals were collected, and MIF levels were measured using ELISA
Disease activity of vasculitis was assessed using the Birmingham Vasculitis Activity Score (BVAS)

Results

Serum MIF levels were higher in the vasculitis pts vs healthy individuals
Among the vasculitis pts, MIF levels were higher in pts in the SVV group vs other groups
In pts with MPA, a positive correlation was observed between serum MIF levels and CRP levels and disease activity (BVAS)
Notably, serum MIF levels were significantly diminished after clinical improvement

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