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See Latest ArticlesNew insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis
British Journal of Dermatology, 08/11/09
Tanaka A et al. – Elucidating the molecular pathology of familial PLCA provides new insight into mechanisms of pruritus in human skin, findings that may have relevance to developing novel treatments for skin itching. This review provides a clinicopathological and molecular update on familial PLCA.
John A. McGrath, 08/11/09
| This paper provides an overview on the molecular pathology of localized cutaneous amyloidosis - an oftentimes itchy skin disorder. The emerging data implicate an abnormaity of cytokine signaling in the skin that involves various interleukin-6 family cytokine receptors, including interleukin-31 signaling. This is a recently discovered cytokine and its overexpression (or that of its receptor) may also be found in other itchy dermatoses such as nodular prurigo and atopic dermatitis. Moreover, blocking the cytokine with antibodies in a mouse model of atopic dermatitis can reduce scratching. Collectively, the work on localized cutaneous amyloidosis and other studies on interleukin-31 suggest that modulation of this cytokine might have a significant role to play in the management of itch. In the future we may see a new class of clinically useful anti-itch medications coming from this research field. |
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Left Ventricular Ejection Time on Echocardiography Predicts Long-Term Mortality in Light Chain Amyloidosis
Journal of the American Society of Echocardiography, 11/04/09
Amyloid arthropathy mimicking seronegative rheumatoid arthritis in multiple myeloma: case reports and review of the literature
Amyloid The Journal of Protein Folding Disorders, 11/18/09
Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome
Hypertension Research, 11/12/09
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