Rheumatology Medical News about Tibiofemoral, Osteoarthritis, Cartilage loss

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Tibiofemoral joint osteoarthritis: Risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis studies
Radiology, 08/03/09

Roemer FW et al. – In participants with minimal baseline cartilage damage, the presence of high body mass index (BMI), meniscal damage, synovitis or effusion, or any severe baseline magnetic resonance (MR)-depicted lesions was strongly associated with an increased risk of fast cartilage loss. These pts may be ideal subjects for preventative or treatment trials.

Methods

Aim was to assess baseline factors that may predict fast tibiofemoral cartilage loss over a 30-mo period
Multicenter Osteoarthritis (MOST) study is a longitudinal study of individuals who have or who are at high risk for knee OA
MR images were read according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) system
Only knees with minimal baseline cartilage damage (WORMS ≤2.5) were included
Fast cartilage loss was defined as a WORMS of at least 5 in any subregion at 30-mo f/u
Relationships of age, sex, BMI, ethnicity, knee alignment, and several MR features to the risk of fast cartilage loss assessed using a multivariable logistic regression model

Results

Of 347 knees, 90 (25.9%) exhibited cartilage loss, and only 20 (5.8%) showed fast cartilage loss
Strong predictors of fast cartilage loss were:
- High BMI
- Presence of meniscal tears
- Meniscal extrusion
- Synovitis or effusion, and
- Any high-grade MR-depicted feature

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