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Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening
Osteoporosis International, 08/11/09

Zhang YP et al. - This replication study confirmed association of 38 single-nucleotide polymorphisms (SNPs) out of 139 SNPs previously reported in three recent genome-wide association studies (GWASs) with bone mineral density (BMD) in an independent US white sample.

Methods

Study aims to verify the potential associations between BMD and candidate genes/loci reported by GWAS of FHS100K, Icelandic deCODE, and UK-NL
8 promising and 131 available sub-promising SNPs were selected
By using genotypic information from Affymetrix 500 K SNP arrays, their associations with BMD was tested in 1,000 unrelated US whites
Fisher's combined probability method was used to quantify the overall evidence of association
BMD was measured by DEXA

Results

Two promising SNPs, rs3762397 and rs3736228, were replicated in the current study
Besides, 36 sub-promising SNPs were replicated at the same significant level
10 SNPs achieved significant combined p<3.6×10^-4 (0.05/139 SNPs, corrected for multiple testing)

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