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See Latest ArticlesAntioxidant effect of Iloprost: current knowledge and therapeutic implications for systemic sclerosis
Rheumatismo, 08/03/09
Erre GL et al. – Many lines of independent research have pointed out the role of oxidative stress as a fascinating pathogenic link between the three main hallmarks of systemic sclerosis (SSc), viz. humoral and cellular immunity activation, microvascular damage and widespread tissue fibrosis. Therefore counteracting oxidative stress may have a favorable impact on clinical features and progression of disease. It is becoming clearer that Iloprost, a synthetic stable analogue of prostacycline, currently employed in the treatment of SSc vascular features, also possess anti–oxidative properties beside its prostaglandin–like vasodilatory and antiaggregant effects.
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