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Tibiofemoral joint osteoarthritis: Risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study
Radiology, 07/31/09

Roemer FW et al. – Study reports that in participants with minimal baseline cartilage damage, the presence of high body mass index (BMI), meniscal damage, synovitis or effusion, or any severe baseline magnetic resonance (MR)-depicted lesions was strongly associated with an increased risk of fast cartilage loss; these pts may be ideal subjects for preventative or treatment trials.

• Aim was to assess baseline factors that may predict fast tibiofemoral cartilage loss over a 30-mo period
• Multicenter Osteoarthritis (MOST) study of individuals who have or who are at high risk for knee OA
• MR images were read according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) system
• Only knees with minimal baseline cartilage damage (WORMS ≤2.5) were included
• Fast cartilage loss was defined as a WORMS of at least 5 in any subregion at 30-mo f/u
• Relationships of age, sex, BMI, ethnicity, knee alignment, and several MR features to the risk of fast cartilage loss were assessed by using a multivariable logistic regression model

• Of 347 knees, 25.9% exhibited cartilage loss, and only 5.8% showed fast cartilage loss
• Strong predictors of fast cartilage loss were:
  • High BMI, presence of meniscal tears, meniscal extrusion,
  • synovitis or effusion, and any high-grade MR-depicted feature

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