Rheumatology Medical News about JDM, MHC, Corticotherapy

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MHC class I and II expression in juvenile dermatomyositis skeletal muscle
Clinical and Experimental Rheumatology Online, 07/30/09

Sallum AME et al. – Study suggest that MHC I expression in muscle fibres is a premature and late marker of juvenile dermatomyositis (JDM) patient independent to corticotherapy; MHC II expression was lower in JDM than in polymyositis (PM) and dermatomyositis (DM).

Methods

Aim was to assess MHC I and II expressions in muscle fibres of JDM and compare with the expression in PM, DM and dystrophy
48 JDM pts and 17 controls (8 PM, 5 DM and 4 dystrophy)
Mean age at disease onset was 7.1±3.0 yrs and the mean duration of weakness before biopsy was 9.4±12.9 mo
Routine histochemistry and IHC for MHC I and II were performed on serial frozen muscle sections in all pts

Results

MHC I expression was positive in 47 (97.9%) JDM cases
This expression was independent of:
- Time of disease
- Corticotherapy previous to muscle biopsy, and
- Grading of inflammation observed in clinical, laboratorial and histological parameters
Expression of MHC I was similar on JDM, PM and DM, and lower in dystrophy
On the other hand, MHC II expression was positive in just 28.2% of JDM cases
It was correlated to histological features as inflammatory infiltrate, increased connective tissue and VAS for global degree of abnormality
MHC II expression was similar in DM/PM and lower in JDM and dystrophy
It was based on the frequency of positive staining rather than to the degree of the MCH II expression