Rheumatology Medical News about Ankylosing spondylitis, AOAS, JOAS

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Clinical characteristics of patients with ankylosing spondylitis in India
Clinical Rheumatology, 07/29/09

Aggarwal R et al. – Study concludes that features of ankylosing spondylitis (AS) in Indian patients were broadly similar to other part of world, with the exception of increased frequency of peripheral arthritis.

Methods

Study describes the full spectrum of clinical, laboratory, and radiological characterization of AS pts in India
Data of 70 consecutive AS pts, was prospectively obtained using investigator-administered questionnaires
Diagnosis was made according to the modified New York criteria
Core set of variables selected by Assessment in AS International society were obtained
Differences in clinical characteristics based on presence or absence of peripheral arthritis, gender, and juvenile (JOAS) vs adult onset AS (AOAS) were evaluated

Results

Male/female ratio was 5:1; mean age of onset of symptoms and diagnosis were 23.6 and 32.5 yrs, respectively
Females had similar spinal indices and radiological damage as male counterpart
However, they had more common extra-articular manifestations and root joint involvement
Majority of pts consisted of AOAS and was clinically similar to JOAS
One or more peripheral joints were involved in 65.7% of pts, affecting predominantly the lower extremity in asymmetrical pattern
Pts with peripheral arthritis had higher ESR, more frequent enthesitis, root joint, and whole spine involvement, suggesting more aggressive disease
Most common site of enthesitis was chondro-sternal junction and Achilles tendonitis
Root joints frequently involved extra-axial joints; uveitis was the most common extra-articular manifestation
Predominant initial symptom was typical inflammatory low back pain
Assessment in AS indices showed a moderately severe disease activity and damage with following values:
- Mean Bath Ankylosing Spondylitis Disease Activity Index, 3.2 (±1.8)
- Mean Bath Ankylosing Spondylitis Functional Index, 2.3 (±2.0); and
- Mean Bath Ankylosing Spondylitis Metrology Index, 3.15 (±2.3)
Majority of the pts had bilateral sacroiliitis (grades 2-4) on radiographs

Exclusive Author Commentary
Dr. Rohit Aggarwal, Dr. Anand N. Malaviya, 07/29/09

We are very pleased to know that our article was considered to be important enough to get selected for publication by MDLinux. We wish to thank the team of MDLinux for the same - Dr. Malaviya

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