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Subclinical atherosclerosis and endothelial dysfunction in young South-Asian patients with systemic lupus erythematosus
Clinical Rheumatology, 07/29/09

Ghosh P et al. – Indian patients with systemic lupus erythematosus (SLE) have higher prevalence of subclinical atherosclerosis and endothelial dysfunction. Presence of damage was associated with abnormal intima-medial thickness (IMT) in SLE patients.

Methods

Study was conducted to find out the prevalence and predictors of carotid IMT and brachial artery flow-mediated dilatation (FMD) in SLE pts from India
Endothelial dysfunction was assessed by FMD in brachial artery
IMT was measured in common carotid artery in SLE pts and healthy controls
60 SLE pts (mean age 31±9 yrs) and 38 healthy controls (mean age 34±6 years)

Results

IMT was higher in SLE pts vs controls
SLE and damage were independent predictors of abnormal IMT
FMD was impaired in SLE pts vs controls
None of the classical cardiovascular risk factors were predictors of FMD or abnormal IMT

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