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See Latest ArticlesIdentification of progressors in osteoarthritis by combining biochemical and MRI-based markers
Arthritis Research & Therapy, 07/29/09
Dam EB et al. – Study demonstrates that the combination of biochemical and MRI-based biomarkers improved diagnosis and prognosis of knee osteoarthritis and may be useful to select high-risk patients for inclusion in disease-modifying osteoarthritis drugs (DMOAD) clinical trials.
Methods- An investigation of whether combinations of biochemical and MRI-based markers provided effective diagnostic and prognostic tools for identifying subjects with high risk of OA progression
- Aggregate cartilage longevity markers combining markers of breakdown, quantity, and quality were tested
- 159 subjects (48% female; age: 56.0 +/- 15.9 yrs; BMI 26.1 +/- 4.2 kg/m2)
- At baseline and after 21 mo, following markers were quantified:
- Biochemical- urinary collagen type II C-telopeptide fragment, CTX-II
- MRI-based- cartilage volume, thickness, area, roughness, homogeneity, and curvature in the medial tibio-femoral compartment
- Joint space width was measured from radiographs and at 21 mo to assess progression of joint damage
- Cartilage roughness had the highest diagnostic accuracy among the individual markers to distinguish subjects with radiographic OA from healthy controls
- Diagnostically, cartilage longevity scored AUC 0.84
- For prediction of longitudinal radiographic progression based on baseline marker values, the individual prognostic marker with highest AUC was homogeneity at 0.71
- Prognostically, cartilage longevity scored AUC 0.77
- When comparing pts in the highest quartile for the longevity score to lowest quartile, the odds ratio of progression was 20.0
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