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Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis
Arthritis Research & Therapy, 07/29/09

Daoussis D et al. – Study reports that uric acid (UA) is a strong correlate of renal dysfunction in rheumatoid arthritis (RA) patients. RA patients with elevated UA may require screening for renal dysfunction and appropriate management.

• An investigation of whether:
  • UA associates with renal dysfunction in pts with RA, and
  • Whether such an association is independent or mediated through other co-morbidities or risk factors for renal impairment
• Renal function assessed in 350 consecutive RA pts by estimated glomerular filtration rate (GFR) using the 6- variable MDRD equation
• Risk factors for renal dysfunction were recorded
• Linear regression used to test the independence of the association between GFR and UA

• Univariable analysis: associations between GFR and age, systolic blood pressure, total cholesterol, triglycerides, RA duration and UA
• UA had the most powerful association with renal dysfunction
• A basic model was created, incorporating all of the above parameters along with BMI and sex
• UA ranked as the first correlate of GFR followed by age
• Adjustments for the following factors did not change the results:
  • Use of medications- diuretics, low dose aspirin, COX-II inhibitors and NSAIDs, and
  • Further adjustment for markers of inflammation and insulin resistance

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