Rheumatology Medical News about Gout, Hyperuricemia, Novel therapies

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Novel therapies for treatment of gout and hyperuricemia
Arthritis Research & Therapy, 07/27/09

Terkeltaub R – Study presents the current scope of therapeutics for gout and hyperuricemia that can be employed more effectively, in particular for refractory gouty inflammation and hyperuricemia, focusing on new urate-lowering drugs (febuxostat and uricases) and biologic approaches to gouty inflammation via IL-1 inhibition.

Promising genomics and imaging technologies have the potential to improve prevention, diagnosis, and therapy by identifying disease earlier and tailoring treatment strategies
Examples include single nucleotide polymorphism and haplotype identification for renal urate transporters in patients with hyperuricemia

Dual energy computed tomography, which is highly sensitive and specific in visualizing tissue stores of monosodium urate crystals as well as renal uric acid urolithiasis has the potential:

To assist in diagnosis of gout in pts with hyperuricemia or joint pain, and
To better quantify tophus dissolution in therapy

The bottom line will remain that gout and hyperuricemia treatments need to be better translated into a collective of favorable outcomes for both control of gouty inflammation and management of hyperuricemia, as well as improved outcomes of gout-related quality of life and co-morbidities.

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