Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
See Latest ArticlesHow to manage patients with systemic lupus erythematosus who are also antiphospholipid antibody positive
Best Practice & Research: Clinical Rheumatology, 07/27/09
Giles I et al. – The purpose of this article is to discuss the significance of a positive antiphospholipid antibodies (aPL) result in patients with systemic lupus erythematosus (SLE) with particular reference to the nature of the aPL test performed and the presence (or absence) of clinical features of APS. The implications of these findings for the management of obstetric and thrombotic complications of antiphospholipid syndrome (APS) in patients with SLE are also discussed as well as the potential impact of any future therapies.
- All pts with suspected or confirmed SLE should have blood tests for aPL; positive test can be one of the criteria for diagnosis of SLE
- Currently widely available tests: anti-cardiolipin ELISA, LA and anti-b2GPI ELISA
- A patient with persistently positive results in any of these tests may develop APS
- If they have not yet developed any features of APS but do have SLE, use of low-dose aspirin is advisable; hydroxychloroquine and/or statins may help too
- Pts with APS characterised by VT should be treated with long-term anticoagulation to prevent recurrent thrombosis
- Pts with APS characterised by PM are treated with aspirin; may also be treated with sc heparin throughout pregnancy
- Newer, more targeted treatments for APS are being developed
Related Articles
A STAT4 risk allele is associated with ischemic cerebrovascular events and antiphospholipid antibodies in Systemic Lupus Erythematosus
Annals of Rheumatic Diseases, 10/23/09
Relevance Score: 79%
Beta2 glycoprotein I (beta2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome
Blood, 10/09/09
Relevance Score: 79%
Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis
Journal of Rheumatology, 11/06/09
Relevance Score: 68%
Low prevalence of hepatitis B virus infection in patients with systemic lupus erythematosus in southern China
Rheumatology International, 10/21/09
Relevance Score: 68%
Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study
Arthritis Research & Therapy, 10/16/09
Relevance Score: 68%
Today in Systemic Lupus (SLE)...keeping you current
Receive free subspecialty "5-minute updates" via email
A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han populationTEST
Rheumatology International, 12/17/09
Serum levels of autoantibodies against C-reactive protein correlate with renal disease activity and response to therapy in lupus nephritis
Arthritis Research & Therapy, 12/16/09
Predictors of the first cardiovascular event in patients with systemic lupus erythematosus - a prospective cohort study
Arthritis Research & Therapy, 12/14/09
Sponsor
Article Search
Sponsor
Sponsor