Rheumatology Medical News about Menopause, Postmenopaue, Hormone, Gout

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Menopause, postmenopausal hormone use and risk of incident gout
Annals of Rheumatic Diseases, 07/22/09

Hak AE et al. - These prospective findings indicate that menopause increases the risk of gout, whereas postmenopausal hormone therapy modestly reduces gout risk.

Methods

Aim was to investigate the relation between menopause, postmenopausal hormone use and risk of gout
92,535 women without gout at baseline were studied
Multivariate proportional hazards regression analysis used to adjust for age, BMI, diuretic use, hypertension, alcohol intake and dietary factors

Results

During 16 yrs of f/u (1,240,231 person-years), 1,703 incident gout cases were documented
The incidence rate of gout increased from 0.6 per 1000 person-yrs in women <45 yrs of age to 2.5 in women ≥75 yrs of age
Compared with premenopausal women, postmenopausal women had a higher risk of incident gout
Among women with natural menopause, women with age at menopause <45 years had a RR of 1.6 of gout vs women with age at menopause 50-54 yrs
Postmenopausal hormone users had a reduced risk of gout

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