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See Latest ArticlesCell-mediated immune responses to influenza vaccination in Wegeners granulomatosis
Annals of Rheumatic Diseases, 07/23/09
Holvast A et al. – Study reports that cell-mediated responses to influenza vaccination in Wegener’s granulomatosis (WG) patients are comparable to those in healthy controls.
Methods- Aim was to determine the antibody and cell-mediated immune responses in the defense against influenza in WG pts
- 25 WG pts and healthy controls received subunit influenza vaccine
- PBMCs were obtained before and 1 month after vaccination
- Cell-mediated responses to A/H1N1 and A/H3N2 were assessed using IFN-γ ELISpot and intracellular cytokine staining for IFN-γ, TNF and IL-2
- Prior to vaccination, patients and controls showed similar recall responses to A/H1N1 and A/H3N2
- Following vaccination, pts and controls showed similar levels of increase in spot-forming cells against A/H1N1 and A/H3N2
- By flow cytometry, upon vaccination, proportions of cytokine-producing CD4+ T-cells increased in pts and controls for A/H1N1 and A/H3N2
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