Rheumatology Medical News about Ankylosing spondylitis, Hip replacement surgery, Risk factors

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Hip involvement in ankylosing spondylitis: Epidemiology and risk factors associated with hip replacement surgery
Rheumatology, 07/20/09

Cruyssen BV et al. – Study reports that the hip involvement is commonly recognized by rheumatologists in ankylosing spondylitis (AS) patients, and involves about 1 out of the 3-4 patients with AS and is associated with impaired functioning reflected by higher overall Bath Ankylosing Spondylitis Functional Index (BASFI) scores. Early onset of disease, axial and enthesial disease are associated with the hip replacement surgery in AS.

Methods

Main objectives of this study were to:
- Describe the epidemiology of clinical and radiological hip involvement, and
- Define the risk factors for the hip replacement surgery in AS pts
Data from 3 datasets were merged: 847 Belgian (ASPECT database), 1405 Spanish (REGISPONSER database) and 466 Ibero-American (RESPONDIA database) AS pts
The ASPECT and REGISPONSER database (Dataset A) were used for exploratory analysis
RESPONDIA database (Dataset B) was used for confirmative analysis
Factors associated with hip involvement and the hip replacement surgery were analysed

Results

24 (REGISPONSER) to 36% (RESPONDIA) of AS pts under rheumatologist's care presented clinical hip involvement, including the 5% (Dataset A) of AS pts who needed hip replacement surgery
Pts with hip involvement had worse overall BASFI scores vs pts w/o hip involvement
Corrected for disease duration, pts with early disease onset, enthesial and axial disease needed most frequently hip replacement surgery

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