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See Latest ArticlesVentricular mass index correlates with pulmonary artery pressure and predicts survival in suspected systemic sclerosis-associated pulmonary arterial hypertension
Rheumatology, 07/21/09
Hagger D et al. – Study concludes that ventricular mass index (VMI) correlates well with mean pulmonary artery pressure (mPAP) in patients with systemic sclerosis (SSc) and may have a role in non-invasively excluding clinically significant pulmonary hypertension (PH) in breathless SSc pts in whom echocardiographic screening has failed.
Methods- Aim was to investigate if VMI may serve as a diagnostic tool to predict the presence or absence of PH in SSc pts
- Details of all consecutive SSc pts undergoing MRI and right heart catheterization were collected prospectively
- Subsequently, the VMI for all pts was calculated, and further baseline data were collected
- Data for 40 pts, 28 of whom were diagnosed with PH at rest (PHREST), were analysed
- VMI correlated strongly with mPAP
- Using a VMI threshold of 0.56, positive predictive value (PPV) for PHREST was 88% and negative predictive value (NPV) was 100%
- Using a threshold of 0.7, PPV was found to be 100% and NPV 53%
- Echocardiographically obtained tricuspid gradient (TG) also demonstrated a strong correlation with mPAP
- 2-year survival in pts with VMI <0.7 and ≥0.7 was 91 and 43%, respectively
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