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All-trans retinoic acid-induced ADAM28 degrades proteoglycans in human chondrocytes
Biochemical and Biophysical Research Communications, 07/15/09
Hikichi Y et al. - The authors found that transfection of ADAM28 or its alternatively spliced soluble form augmented proteoglycan release in the cell assay; however, a mutant soluble form in which a portion of the disintegrin domain was deleted did not have proteoglycan-releasing activity, implying the importance of the domain for enzyme localization and substrate recognition for cartilage degradation in OA.
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