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Temporomandibular joint osteoarthritis: An open label trial of 76 patients treated with arthrocentesis plus hyaluronic acid injections
International Journal of Oral and Maxillofacial Surgery, 07/15/09

Manfredini D et al. – Data support the usefulness of serial hyaluronic acid injections performed after arthrocentesis for the treatment of temporomandibular joint (TMJ) osteoarthritis and for the maintenance of improvements over a 6-month follow-up period.

• An open-label trial on a sample of 76 consecutive pts with TMJ OA treated with a cycle of 5 weekly arthrocenteses plus hyaluronic acid injections
• Patients had a diagnosis of OA according to RDC/TMD Axis I Group IIIb
• They underwent a cycle of 5 arthrocenteses with injections (1 per week) of 1 ml hyaluronic acid and 4 f/u assessments after the end of the treatment (at 1 wk, 1, 3, and 6 mo)
• At each appointment, several subjective and objective outcome variables were assessed to test the efficacy of the treatment protocol

• Marked improvements were reported for all variables during the treatment phase
• The improvements were maintained over the 6-mo f/u period
• The p-value of the multivariate permutation test for the efficacy of the treatment over time was 0.001
• Significant changes at the end of the f/u period were detected for almost all the outcome variables

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