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See Latest ArticlesLong-term beneficial effects of statins on vascular manifestations in patients with systemic sclerosis
Modern Rheumatology, 07/15/09
Kuwana M et al. – Study suggests that statins may be beneficial in treating vascular manifestations of systemic sclerosis (SSc), through their pleiotropic effects. However, this treatment did not correct the defect in endothelial progenitor cells (EPC) recruitment.
Methods- A 24-month, open-label trial to evaluate the long-term effects of statins on vascular symptoms in pts with SSc
- 10 pts received 10 mg/day atorvastatin; 2 dropped out to treat other organ involvement
- Markers assessed in 8 pts:
- Raynaud’s phenomenon
- Global measures of health
- Psychological scales
- Circulating angiogenic factors and
- Endothelial activation/injury Circulating EPCs
- by cell sorting and three-color flow cytometry at 0 (pretreatment), 1, 3, 12, and 24 months of treatment
- No AEs; Raynaud’s phenomenon improved during atorvastatin treatment, with reductions in Raynaud’s Condition Score and patient assessment by VAS
- SSc-associated upregulation of angiogenic factors and vascular endothelial activation/injury markers were reduced
- Improvement in these parameters was best at 12 and 24 mo of treatment
- The EPC number was increased at 1 mo of treatment, but soon dropped below baseline
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