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Assessment of alveolar epithelial permeability with Tc-99m DTPA aerosol scintigraphy in patients with Sjogren syndrome
Rheumatology International, 07/14/09

Pirildar T et al. – Results of this preliminary study suggest that one can detect pulmonary involvement by technetium-99m diethylene triamine penta-acetic acid (Tc-99m DTPA) aerosol inhalation scintigraphy in patients with primary Sjögren’s syndrome (SjS).

• Aim was to assess the use of Tc-99m DTPA aerosol inhalation scintigraphy in the study of the pulmonary membrane permeability in pts with primary SjS
• 18 pts with primary SjS and 13 healthy controls were investigated
• Clinical evaluation, chest X-ray examination, pulmonary function tests, Tc-99m DTPA aerosol scintigraphy were performed in all the cases
• Presence of respiratory symptoms (dyspnea and cough), duration of sicca symptoms were recorded

• Clearance half time of Tc-99m DTPA radioaerosols in pts with SjS was faster when compared to normal controls
• There was significant increase in lung permeability in pts with SjS compared to the controls
• There was also a significant difference between PI of pts with SjS and that of controls

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