Rheumatology Medical News about Sjögren’s syndrome, Tc-99m DTPA aerosol inhalation scintigraphy, Pulmonary epithelial permeability

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Assessment of alveolar epithelial permeability with Tc-99m DTPA aerosol scintigraphy in patients with Sjogren syndrome
Rheumatology International, 07/14/09

Pirildar T et al. – Results of this preliminary study suggest that one can detect pulmonary involvement by technetium-99m diethylene triamine penta-acetic acid (Tc-99m DTPA) aerosol inhalation scintigraphy in patients with primary Sjögren’s syndrome (SjS).

Methods

Aim was to assess the use of Tc-99m DTPA aerosol inhalation scintigraphy in the study of the pulmonary membrane permeability in pts with primary SjS
18 pts with primary SjS and 13 healthy controls were investigated
Clinical evaluation, chest X-ray examination, pulmonary function tests, Tc-99m DTPA aerosol scintigraphy were performed in all the cases
Presence of respiratory symptoms (dyspnea and cough), duration of sicca symptoms were recorded

Results

Clearance half time of Tc-99m DTPA radioaerosols in pts with SjS was faster when compared to normal controls
There was significant increase in lung permeability in pts with SjS compared to the controls
There was also a significant difference between PI of pts with SjS and that of controls

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