Rheumatology Medical News about FDG-PET/CT, Large-vessel vasculitis, Systemic inflammation

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FDG-PET/CT in large-vessel vasculitis: Its diagnostic and follow-up role
Rheumatology International, 07/15/09

Stenova E et al. – Study reports a case of a patient with FDG-PET/CT findings of large-vessel vasculitis with follow-up results over time to monitor response to anti-inflammatory and immunosuppressive treatment, and concludes that [18F]FDG-PET/CT is an effective combination of imaging modalities in assessing the activity and extent of large-vessel vasculitis with high sensitivity and specificity.

This case illustrates an atypical clinical presentation of large-vessel vasculitis with no clinical symptoms of organ damage
Only symptoms of the patient were signs of systemic inflammation which are common in fever of unknown origin (FUO)
The large-vessel vasculitis is considered to be the cause in 17% of all FUO pts
FDG-PET is a non-invasive diagnostic method; fluoro-deoxyglucose accumulates in tumour cells but also in inflammatory tissue due to the over-expression of glucose transporter (GLUT) and overproduction of glycolytic enzymes
FDG-PET is highly effective in detecting large-vessel vasculitis anywhere in the body and has high sensitivity (77–100%) and specificity (89–100)

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