Rheumatology Medical News about Osteoarthritis, Hand, Bone mineral density

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Lower bone mineral density of forearm in postmenopausal patients with radiographic hand osteoarthritis
Rheumatology International, 07/15/09

Kim SK et al. – This study shows that the bone mineral density (BMD) levels of the distal radius in patients with radiographic hand OA were significantly lower vs controls. Forearm BMD levels were positively associated with age and K–L radiological grade in total hand OA, whereas age and menopausal duration were closely related with radiographic hand OA.

Methods

Main objectives of this study were to:
- Investigate the difference in forearm BMD between radiographic hand OA and non-radiographic hand OA, and
- Association between clinical parameters of pts and the level of forearm BMD
180 postmenopausal pts with hand OA; classified into 2 groups according to K–L radiological grade:
- one with radiographic hand OA (K–L grade ≥2) and
- other with non-radiographic OA (K–L grade <2) as controls
Number of nodal joints, swollen joints and tender joints were determined in the physical examination
Measures of BMD, Australian Canadian (AUSCAN) OA hand index, grip strength, pinch strength, and VAS were also estimated

Results

Pts with radiographic hand OA had lower distal radius BMD vs controls
After adjusting for age, menopausal duration, number of nodal joints, and AUSCAN function index, the difference in BMD between 2 groups was also different
For analysis of risk factors for forearm BMD in hand OA:
- Age and K–L OA grade in total hand OA were considered risk factors
- Age and menopause duration contribute to the forearm BMD in radiographic hand OA pts
Development of osteoporosis at the distal radius in radiographic hand OA was associated with older age, lower BMI, and lower stiffness in the AUSCAN OA index

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Assessing Fracture Risk and Effects of Osteoporosis Drugs: Bone Mineral Density and Beyond
American Journal of Medicine, 10/28/09 Relevance Score: 81%