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See Latest ArticlesThe effects of hormone replacement therapy on autoimmune disease: Rheumatoid arthritis and systemic lupus erythematosus
Climacteric, 07/13/09
Holroyd CR et al. – Review discusses the effect of sex hormones on the rheumatic autoimmune diseases, with particular emphasis on systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Main points of discussion:
- There is much evidence supporting the role of estrogen in the pathogenesis of SLE
- SLE occurs much more frequently in women, especially during the yrs of child-bearing potential, and commonly flares during pregnancy
- Exogenous estrogens have been historically avoided in women with SLE
- Current evidence from prospective trials suggests that there may be a small increased risk of mild/moderate flares in women with SLE taking hormone replacement therapy (HRT)
- In RA, HRT does not appear to be associated with an increased risk of disease flare and may actually improve disease activity
- In all individuals with autoimmune disease, the risk of venous thrombosis associated with oral HRT is an important factor that should also be considered
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Today in Autoimmune/Heritable...keeping you current
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Comparison of autoinflammation and autoimmunity using TRAPS and rheumatoid arthritis as prototypes of these conditions
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Today in Clinical Pharmacology...keeping you current
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