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Renal involvement in Behcet's disease
Saudi Journal of Kidney Diseases and Transplantation, 07/23/09
Ardalan MR et al. – Study concludes that renal involvement in Behcet's disease (BD) is not infrequent, although in most cases it is mild in nature and may be missed.
Methods- An investigation of the frequency and type of renal involvement in BD pts in Azerbaijan province, one of the prevalent areas of BD in Iran
- All cases of BD were evaluated for renal dysfunction in a f/u between June 2004-Jan 2007, and evaluated for:
- Serum creatinine > 1.7 mg/dL
- Glomerular hematuria and proteinuria
- Those pts with proteinuria >500 mg/d and serum creatinine level >2 mg/dL, underwent renal biopsy
- 100 pts, 6% had obvious renal involvements
- 4 pts had glomerular hematuria and proteinuria
- Renal biopsy in 2 of them revealed measangial proliferative glumerulonephritis with IgA deposit in 1 of them and membranoproliferative glumerolonephritis in another one
- 2 remaining pts had serum creatinine >2 mg/dL w/o any hematuria or proteinuria
- Serologic study for viral agents and collagen vascular disease were negative in all pts with renal involvements
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