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See Latest ArticlesCoronary atherosclerosis using computed tomography coronary angiography in patients with systemic sclerosis
Scandinavian Journal of Rheumatology , 07/14/09
Mok MY et al. – Study concludes that the coronary atherosclerosis is not uncommon in asymptomatic systemic sclerosis (SSc) patients; computed tomography coronary angiography (CTCA) is a convenient and non-invasive method for studying coronary atherosclerosis.
Methods- Aim was to examine the frequency of coronary atherosclerosis in SSc pts by CTCA, and to explore its clinical associations
- 19 pts (6 with diffuse; dSSc, and 13 with limited disease; lSSc) with disease duration of ≥3 yrs
- Coronary calcium score and contrast angiography were examined by CT scan
- Conventional cardiovascular factors and inflammatory markers were measured and correlated with CT findings
- Mean age of pts: 52.5 yrs with median disease duration of 12.5 yrs
- 31.6% pts had coronary artery calcification (calcium score 13-2008)
- Coronary calcium was detected in 1 dSSc patient but contrast angiography was not performed because of interference from an in situ implantable cardiac device
- Some parts of the coronary arteries were not assessable in 2 pts who had ectopic cardiac rhythm
- 5 lSSc pts had calcified plaques causing variable coronary luminal stenosis
- All pts were asymptomatic
- Pts with abnormal CTCA findings were more likely to be older and were less likely to have serum anti-Scl70 Abs than those w/o, after Bonferroni correction
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