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Homocysteine levels in patients with Behçets disease and patients with recurrent aphthous stomatitis
Clinical Rheumatology, 07/10/09

Gonul M et al. – Study reports that no differences in homocysteine, vitamin B12, and folic acid levels could be found between Behçet disease (BD) and recurrent aphthous stomatitis (RAS) patients and controls; possibly due to the fact that the patients included in this study mostly had cutaneous symptoms rather than vascular involvement.

Methods

A comparison of the levels of homocysteine, vitamin B12, and folic acid of BD pts vs those with RAS pts and healthy controls
45 BD pts, 47 RAS pts, and 69 healty control subjects
Vitamin B12, folic acid, and homocysteine levels of pts and controls were measured and differences determined

Results

BD pts had mostly cutaneous symptoms
Arthritis and ocular and vascular involvement were seen in 24.4%, 22%, and 11% of BD pts, respectively
No difference was detected among the groups in the levels of vitamin B12, folic acid, and homocysteine
No difference in any parameters according to sex and age of the pts and activity of BD and if the pts with BD were treated or not
Homocysteine level inversely correlated with vitamin B12 and folic acid levels in the BD group

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