Rheumatology Medical News about CRP, SLE, Vascular disease

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C-reactive protein in systemic lupus erythematosus
Autoimmunity, 07/13/09

Batuca J et al. – Article outlines the multiple roles of C-reactive protein (CRP) in the pathogenesis of auto-immune and inflammatory responses, making it an important tool in the clinical management of patients.

CRP activates the classical complement pathway in a controlled fashion, enhancing the capacity for defence against bacterial infections
It plays a protective role against pathogenic autoimmune responses in general, and systemic lupus erythematosus in particular
CRP is also associated with atherosclerosis, both in the general population and in different auto-immune conditions
It plays a double role as a biomarker for vascular risk and as an independent risk factor as it can also perpetuate the inflammatory response

As a marker of increased inflammation and as a risk factor for further disease activity and damage, CRP is a crucial factor in the understanding of the pathogenesis of vascular disease as well as in the clinical management of patients with and without SLE.

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