Rheumatology Medical News about Hand osteoarthritis, CRx-102,

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The responsiveness of joint counts, patient-reported measures and proposed composite scores in hand osteoarthritis: Analyses from a placebo-controlled trial
Annals of Rheumatic Diseases, 07/10/09

Haugen IK et al. – Study reports that the patient-reported pain and patient global assessment were the most responsive outcomes in patients with hand osteoarthritis (HOA) treated with CRx-102, while joint counts had similar responsiveness as patient-reported stiffness and physical function. Composite scores were as responsive as VAS pain.

Methods

An evaluation of the responsiveness of joint counts, patient-reported measures and proposed composite scores in HOA
Data from previous study in which 83 pts were randomized to CRx-102 or placebo
CRx-102 consists of prednisolone (3 mg /d) and dipyridamole (400 mg /d), and was shown to be superior to placebo
Assessments were performed at baseline and after 7, 14, 28 and 42 days, and included:
- AUSCAN, VAS pain and patient global, and
- Counts of DIP, PIP, MCP and CMC joints (tenderness, soft tissue swelling, bony enlargement, limited motion)
Various combinations of patient-reported outcomes and joint counts were computed as composite scores and tested for responsiveness
For each measure, mean change from baseline to Day 42, treatment effect, standardized response mean (SRM) and relative efficiency compared to AUSCAN pain was calculated

Results

SRMs were largest for VAS patient global, VAS pain , and AUSCAN pain
While the responsiveness of tender and swollen joint counts was similar to AUSCAN stiffness and physical function
Composite scores showed similar responsiveness as patient-reported pain and global

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