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Sodium-dependent phosphate cotransporter type 1 (NPT1) sequence polymorphisms in male patients with gout
Annals of Rheumatic Diseases, 07/10/09

Urano W et al. – Data suggest that SLC17A1 (gene that encodes a urate transporter, sodium-dependent phosphate cotransporter type 1; NPT1) polymorphisms are associated with the development of gout.

Methods

Study investigates the roles of SLC17A1 in the development of gout
Male pts with gout (n=175) and male controls (n=595)
SNPs in the human SLC17A1 gene (rs1165176, rs1165151, rs1165153, rs1165196, rs1165209, rs1165215, rs1179086, rs3799344, and rs3757131) were selected for analysis

Results

No differences between gout and control groups in the distribution of genotypes at rs1165196, rs1179086, and rs3757131
In controls, T806C alone had no effect on serum uric acid (sUA) levels
However, T806C showed significant interaction with reduction of sUA in obese individuals (BMI ≥25) using multiple regression analysis

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