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See Latest ArticlesEULAR Sjogrens Syndrome Disease Activity Index (ESSDAI): Development of a consensus systemic disease activity index in primary Sjogrens syndrome
Annals of Rheumatic Diseases, 07/10/09
Seror R et al. – The EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) is a clinical index designed to measure disease activity in patients with primary SS. Once validated, such a standardized evaluation of primary SS should facilitate clinical research and should be helpful as an outcome measure in clinical trials.
Methods- Study aims to develop a disease activity index for pts with primary SS: ESSDAI
- 39 SS experts participated in an international collaboration, promoted by EULAR, to develop the ESSDAI
- Experts identified 12 organ-specific "domains" contributing to disease activity
- For each domain, features of disease activity were classified in 3 or 4 levels according to their severity
- Data abstracted from 96 pts were used to generate 702 realistic vignettes for which all possible systemic complications were represented
- Using the 0-10 physician global assessment (PhGA) scale, each expert scored the disease activity of 5 patient profiles and 20 realistic vignettes
- All 12 domains were associated with disease activity in the multivariate model, domain weights ranged from 1 to 6
- ESSDAI scores varied from 2 to 47 and were significantly correlated with PhGA for both real patient profiles and realistic vignettes
- Compared to 57 (59.4%) of the real patient profiles, 468 (66.7%) of the realistic vignettes were considered likely or very likely to be true
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The immunoregulatory role of vitamins A, D and E in patients with primary Sjogren's syndrome
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