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See Latest ArticlesHealth-related quality of life in patients with primary Sjögrens syndrome: Relationship with serum levels of proinflammatory cytokines
Scandinavian Journal of Rheumatology , 07/09/09
Baturone R et al. – Study reports that patients with primary Sjogren's syndrome (pSS) showed increased levels of several macrophage- and lymphocyte-derived cytokines, indicating the existence of an immune activation state. Serum levels of one of these cytokines, IL-6, were correlated with poor quality of life in these individuals.
Methods- A cross-sectional study of 30 pSS pts to analyze the health-related quality of life (HRQoL) and its relationship with serum levels of macrophage- and lymphocyte-derived cytokines
- HRQoL was evaluated using SF-36
- Serum levels of IL-1β, IL-6, IL-10, TNF-α, and γ-INF were analysed by a sandwich immunoassay-based protein array system
- Each of the 8 scales of the SF-36, physical composite score (PCS) and the mental composite score (MCS), showed a decrease in pSS pts
- Similarly, pts with pSS showed increased concns of each of the 5 cytokines vs healthy control
- In pSS pts, a negative correlation was detected between serum levels of IL-6 and the PCS of the SF-36
- Those pts with concns of IL-6 higher than healthy controls showed a lower score in the dimensions of bodily pain and physical functioning, and in PCS
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