Rheumatology Medical News about TLR-9, Nephritis, Renal lupus

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Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: Implications for the amplification of the inflammatory response
Lupus, 07/17/09

Papadimitraki ED et al. – This study documents for the first time the up-regulation of toll-like receptor-9 (TLR-9) within the glomerulus of patients with lupus nephritis. Activation of TLR-9 expressing glomerular cells by endogenous nucleic acids (nucleosomes) may amplify the inflammatory response.

Methods

Study investigates the expression of TLR-9 in the renal tissue of pts with lupus
TLR-9 expression was studied in kidneys of 12 lupus and 10 control samples from macroscopically unaffected areas of pts with renal adenocarcinoma by IHC
A semiquantitative score was assigned separately for tubular, interstitial and glomerular expression

Results

TLR-9 was expressed in the renal tubules and interstitial tissue in both pts with lupus and controls
6 of 12 pts with lupus with proliferative or membranous nephritis vs none of the controls, exhibited both tubulointerstitial and glomerular TLR-9 expression
Biopsies with glomerular TLR-9 expression had a higher activity index

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