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See Latest ArticlesThe causes and clinical significance of fever in systemic lupus erythematosus: A retrospective study of 487 hospitalised patients
Lupus, 07/09/09
Zhou WJ et al. – Data suggest that the infection and disease activity are the most common causes of fever in systemic lupus erythematosus (SLE). Those patients for whom SLE fever could not be suppressed by a higher dose of steroids usually had severe lupus encephalopathy or hemophagocytic syndrome.
Methods- Aim was to investigate the causes and characteristics of fever in SLE
- Medical records of 1949 consecutive pts hospitalised for SLE from Jan 2002 to May 2007 were reviewed
- A total of 487 SLE-hospitalised pts with fever were identified and retrospectively analysed
- Among them causes of fever were:
- 265 pts had fever from infection
- 206 had fever related to SLE
- 8 had fever caused by both SLE activity and infections
- 4 had fever caused by malignancies and
- 4 had fever ascribed to miscellaneous causes
- Most common sites of infection: respiratory tract, urinary tract, skin and mucosa
- A prednisone dose of ≤100 mg/d was able to suppress SLE fever in 80.6% of the pts, usually within 1-5 days
- Compared to pts with infection fever, those with SLE fever were more likely to have lower serum complement C3 and a higher SLE Disease Activity Index score
- Infection fever was found to be associated with the use of azathioprine within the last 6 months
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Interferon-[alpha] mediates suppression of C-reactive protein: Explanation for muted C-reactive protein response in lupus flares?
Arthritis & Rheumatism, 12/07/09
Sleep disturbance in lupus patients
International Journal of Clinical Rheumatology, 12/07/09
Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population
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