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See Latest ArticlesAdipocytokines in systemic lupus erythematosus: Relationship to inflammation, insulin resistance and coronary atherosclerosis
Lupus, 07/09/09
Chung CP et al. – Study concludes that patients with systemic lupus erythematosus (SLE) have increased concentrations of adiponectin, leptin and visfatin. Lower concentrations of adiponectin and higher concentrations of leptin are associated with insulin resistance, body mass index (BMI) and C-reactive protein (CRP) in patients with SLE.
Methods- Aim was to investigate if:
- Concentrations of adipocytokines are altered in SLE and
- If they are associated with coronary atherosclerosis, insulin resistance and inflammation
- Concns of resistin, leptin, adiponectin and visfatin were measured in 109 pts and 78 control subjects
- Coronary calcification was measured using electron beam-computed tomography
- Insulin resistance was defined by the homeostasis model assessment index
- Concns of adiponectin, leptin, and visfatin were higher in pts vs controls
- These differences remained significant after adjustment for age, race, sex and BMI
- Concns of resistin did not differ in pts and controls
- In pts with SLE, leptin was positively associated with BMI, insulin resistance, and CRP
- Whereas adiponectin was negatively associated with the same factors
- None of the adipocytokines were associated with coronary atherosclerosis in SLE
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