Rheumatology Medical News about Neonatal lupus erythematosus, Ro/SSA, La/SSB, Congenital heart block

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Serologic follow-up of children born to mothers with Ro/SSA autoantibodies
Lupus, 07/17/09

Klauninger R et al. – These findings support a role for placental materno-foetal transfer of IgG autoantibodies in the pathogenesis of neonatal lupus erythematosus (NLE) and indicate that refraining from breastfeeding does not protect from NLE skin involvement.

Methods

An investigation of the postnatal Ro and La IgG, IgA and IgM antibody levels up to 1 year of age in 32 children born to Ro/SSA positive mothers
Antibody levels were correlated with NLE manifestations
Role of breast feeding in transfer of autoantibodies from mother to child was evaluated

Results

Ro52, Ro60 and La IgG Abs all transferred from the mothers to their foetus in utero and were present in the infant at birth
A significant decrease in Ro52, Ro60 and La IgG Ab levels of the infants was observed from birth to 4-5 wks of age
Ro- and La-specific IgA and IgM Abs were detected in the serum from a subset of mothers
However, Ro- and La-specific IgA and IgM Ab levels were low or non-detectable in children raised both with and w/o breastfeeding
Furthermore, NLE skin lesions developed independently of breastfeeding

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