Rheumatology Medical News about T-lymphocyte, Lupus, Apoptosis, SLE, ANA

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Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: A cross-sectional and longitudinal study
Lupus, 07/17/09

Dhir V et al. – Study confirms a higher degree of apoptosis in T-lymphocytes in patients with lupus erythematosus (SLE) and found a direct correlation of T-cell apoptosis with disease activity. Patients had reduced T-cell frequency, which inversely correlated with T-cell apoptosis and may suggest a cause-effect relationship.

Methods

Main objectives of this study were to:
- Measure T- and B-lymphocyte apoptosis in lupus pts
- Look at the effect of disease activity in a cross-sectional and longitudinal design
- Determine frequency of T and B cells, level of anti-nucleosomal antibodies (ANA) and serum IL 10 and assess their relationship with apoptosis
41 pts with SLE and 20 controls
A cutoff value of 4 in SLEDAI was used to separate active from inactive SLE
Frequency and degree of apoptosis of T and B lymphocyte were enumerated by flow cytometry using PBMCs stained with CD3/CD19 and annexin V/PI
Data for T/B cell frequency are represented as % of these cells in the PBMC population
Percentage of apoptotic cells is out of total T or B cells
Serum ANA and IL 10 were assayed using ELISA
A repeat assessment of these parameters was carried out in 11 active pts when they became inactive

Results

Higher T-lymphocyte apoptosis in pts with SLE vs controls and a lower frequency of T cells was observed
T-lymphocyte apoptosis was higher in pts with active disease vs inactive
Further, T-lymphocyte apoptosis directly correlated with SLEDAI and inversely with T-cell frequency
Anti-nucleosomal Abs correlated with SLEDAI but not apoptosis
On longitudinal f/u, a decline in T-cell apoptosis was seen in pts with SLE, however not statistically significant

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