Rheumatology Medical News about Sjogrens Syndrome;cytokine and autoantibody profiling

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Cytokine and autoantibody profiling related to histopathological features in primary Sjögren's syndrome
Rheumatology, 07/08/09

Reksten TR et al. – Degenerative changes observed in the minor salivary glands of patients with primary SS (pSS) may represent ‘burned out’ inflammation. Differences in cytokine levels observed as described in this study may be utilized when sub-grouping the SS patients into disease phases and may consequently have implications for treatment.

Methods

An investigation of a potential correlation between circulating cytokine and autoantibody levels and histopathological features in subgroups of pts with pSS
Minor salivary gland biopsies from 141 pts were re-examined and grouped according to focus score (FS) and germinal centre (GC) status
Serum samples were analysed for autoantibodies, chemokines and cytokines

Results

16% of biopsies lacked characteristic focal mononuclear cell infiltrates
However these pts were positive for Ro/SSA and/or La/SSB. IL-17, IL-1RA, IL-15, macrophage inflammatory protein (MIP)-1α, MIP-1β, eotaxin, IFN-α
IL-4 levels were significantly increased in the 23% pts with ectopic GC formation (GC+) in the salivary glands vs GC- pts
In addition, minor differences in cytokine levels were found when comparing age groups

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