Rheumatology Medical News about streptococcal cell wall-induced arthritis;apoptotoc cell-mediated supression;local regulartory T cell increase;alteration of macrophage function

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Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T cell increase: A potential cell-based therapy?
Arthritis Research & Therapy, 07/07/09

Perruche S et al. – Data indicate that apoptotic cells modulate macrophage function and result in regulatory T cells (Treg) generation/increase. This may be involved in inhibition of inflammation and amelioration of arthritis, confirming that in vivo generation of Tregs using apoptotic cell injection may be a useful tool to prevent and treat inflammatory autoimmune responses.

Methods

An evaluation of the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats
Rat apoptotic thymocytes were injected i.p. (2.10e8) in addition to an arthritogenic dose of systemic SCW in LEW female rats
Control rats received SCW immunization and PBS
Rats were then followed for arthritis occurrence and circulating cytokine detection
At sacrifice, Treg and macrophages were analyzed

Results

Apoptotic cell injection profoundly suppressed joint swelling and destruction typically observed during the acute and chronic phases of SCW-induced arthritis
Synovial inflammatory cell infiltration and bone destruction were also markedly suppressed

Ex vivo experiments revealed reduced levels of TNF in cultures of macrophages from rats challenged with SCW in the presence of apoptotic thymocytes as well as reduced macrophage response to lipo-polysaccharide (LPS)

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