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Molecular therapies for systemic lupus erythematosus: Clinical trials and future prospects
Arthritis Research & Therapy, 07/06/09

Monneaux F et al. - The aim of this review article is to highlight emerging pharmacological options and new therapeutic avenues for lupus with a focus on non-antibody molecular strategies, particularly fusion proteins, peptides and small molecules that represent excellent alternative tools for immune intervention.

Novel targets in the treatment of lupus patients- ongoing therapeutic trials:

  • Cell surface-expressed molecules
  • Compounds targeting intracellular components
  • Agents that modulate the hormonal pathway
  • Modulation of sex steroid hormones
  • Inhibition of prolactin
  • Autoantigens

    Although the current literature search shows a number of promising molecules that are impressively efficient in murine models of lupus, very few of these molecules reach the standard required for evaluating them in clinical trials. Managing patients with SLE is challenging and new treatments are eagerly awaited.

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    Today in Systemic Lupus (SLE)...keeping you current

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     See all of Systemic Lupus (SLE)

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