Rheumatology Medical News about immunogenetic prognostic factors;ankylosing spondylitis;radiographic severity

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Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis
Arthritis Care and Research , 07/06/09

Ward MM et al. – Findings suggest that the accuracy of the prognosis of radiographic severity in ankylosing spondylitis (AS) is improved by knowing the age at disease onset, sex, smoking history, and the presence of HLA-B*4100, DRB1*0804, DQA1*0401, DQB1*0603, DRB1*0801, and DPB1*0202 alleles.

Methods

Aim was to identify demographic, clinical, and immunogenetic characteristics associated with radiographic severity in AS pts to improve prognostic ability
AS pts for 20 yrs were enrolled in a cross-sectional study (n=398)
Pelvic and spinal radiographs were scored using Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s)
Radiographic severity was measured as the BASRI-s/duration of AS
Clinical factors and HLA-B, DR, DQ, and DP alleles associated with highest quartile of distribution of radiographic severity were identified
Similar procedures were used to identify factors associated with lowest quartile of radiographic severity

Results

Radiographic severity was associated with older age at onset of AS, male sex, current smoker, and the presence of HLA-B*4100, DRB1*0804, DQA1*0401, DQB1*0603, and DPB1*0202
Whereas the presence of DRB1*0801 was strongly negatively associated
Being in the lowest quartile of BASRI-s/duration of AS was also less likely among those with an older age at onset of AS, men, and current smokers

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