Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Rapid correction of low vitamin D status in nursing home residents 3. 2008 Exclusive Survey—Earnings: Good news for primary care income 4. Medicare pay-for-reporting effort draws fire from frustrated doctors 5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment
Top Ten Searches
rheumatoid arthritis lupus polymyalgia sjogrens fibromyalgia amyloidosis vasculitis urate raynauds myositisYour Article Summary
See Latest ArticlesAssociation of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains
Arthritis & Rheumatism, 07/08/09
Vargas-Alarcón G et al. – Findings suggest that adrenergic receptor (AR) gene polymorphisms are related to the risk of developing fibromyalgia (FM) and are also linked to different domains of the FM syndrome.
Methods- Aim was to correlate α-AR and β-AR gene polymorphisms with the presence of FM and different domains of FM syndrome
- 78 Mexican FM pts vs 48 age-matched controls, and 78 Spanish FM pts vs 71 controls (all women)
- SNPs of α1A-AR (rs574584, rs1383914, rs1048101, and rs573542), β2-AR (rs1042713 and rs1042714), and β3-AR (rs4994) were analyzed
- Polymorphic haplotypes were constructed after linkage disequilibrium analysis
- β2-AR AC haplotype was a risk factor for presence of FM
- This haplotype had an increased frequency in Mexican pts vs Mexican controls
- Similarly, 50.4% of Spanish pts had this haplotype vs 40.0% of Spanish controls
In Spanish pts, the α1A-AR SNP rs1383914 was associated with presence of FM - α1A-AR SNP rs1048101 was linked with FIQ disability
- Mexican pts with rs574584 GG genotype presented the highest FIQ score vs Mexican pts with other genotypes
- In Mexicans SNP rs574584 was associated with FIQ morning stiffness and with FIQ tiredness upon awakening
Related Articles
Fibromyalgia Syndrome Module at OMERACT 9: Domain Construct
Journal of Rheumatology, 10/15/09
Relevance Score: 80%
Content and Criterion Validity of the Preliminary Core Dataset for Clinical Trials in Fibromyalgia Syndrome
Journal of Rheumatology, 10/15/09
Relevance Score: 79%
Are chronic fatigue syndrome and fibromyalgia the same? Implications for the provision of appropriate mental health intervention
Journal of Psychiatric and Mental Health Nursing, 11/16/09
Relevance Score: 69%
The Predetermined Sites of Examination for Tender Points in Fibromyalgia Syndrome Are Frequently Associated With Myofascial Trigger Points
The Journal of Pain, 11/17/09
Relevance Score: 68%
Fibromyalgia and Myofascial Pain Syndrome - A Dilemma
Indian Journal of Anaesthesia, 10/22/09
Relevance Score: 68%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Low cortisol levels in active juvenile idiopathic arthritis
Clinical Rheumatology, 12/20/09
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
Rheumatology, 12/20/09
The 'RASor's' edge: Ras proteins and matrix destruction in arthritis
Arthritis Research & Therapy, 12/19/09
Today in Chr Fatigue/Fibromyalgia...keeping you current
Receive free subspecialty "5-minute updates" via email
Clues on the MDHAQ to Identify Patients with Fibromyalgia and Similar Chronic Pain Conditions
Rheumatic Disease Clinics of North America, 12/08/09
Chronic widespread pain and fibromyalgia: Two sides of the same coin?
Current Rheumatology Reports, 12/04/09
Continuing Medical Education Challenges in Chronic Fatigue Syndrome
BMC Medical Education, 12/04/09
Sponsor
Article Search
Sponsor
Sponsor