Rheumatology Medical News about systemic sclerosis;cerebral vasculopathy;severe vascular manifestations

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Cerebral vasculopathy is associated with severe vascular manifestations in systemic sclerosis
Journal of Rheumatology, 07/02/09

Terrier B et al. – Findings suggest that severe cerebral vasculopathy is associated with severe vascular manifestations in systemic sclerosis (SSc) patients. These patients should undergo neuroradiological imaging assessment of brain involvement.

Methods

An investigation of the brain involvement in pts with SSc
63 pts; 30 (47.6%) with limited cutaneous and 27 (42.9%) with diffuse cutaneous SSc
41 pts underwent CT scan and MRI of brain, 11 pts only CT scan, and 11 pts only MRI
Cerebral vasculopathy on MRI and CT scan was defined as: absent or mild, moderate, or severe on a 4-point scale (0-3)

Results

Cerebral vasculopathy was identified on CT scan in 22 pts and on MRI in 38 pts
Pts with severe cerebral vasculopathy seen on MRI were more likely to have pulmonary arterial hypertension (PAH) and showed a tendency to have scleroderma renal crisis
A similar association was found between severe cerebral vasculopathy seen on CT scan and PAH or SRC
After adjusting for age and hypertension, severe cerebral vasculopathy was still associated with increased risk of severe vascular manifestations

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