Rheumatology Medical News about Methotrexate therapy;active rheumatoid arthritis;Golimumab

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Rapid correction of low vitamin D status in nursing home residents

3. 2008 Exclusive Survey—Earnings: Good news for primary care income

4. Medicare pay-for-reporting effort draws fire from frustrated doctors

5. Allopurinol-induced recurrent dress syndrome: Pathophysiology and treatment

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

E-selectin, interleukin 18, serum amyloid A, and matrix metalloproteinase 9 are associated with clinical response to golimumab plus methotrexate in patients with active rheumatoid arthritis despite methotrexate therapy
Journal of Rheumatology, 07/02/09

Visvanathan S et al. – Study demonstrates that treatment with golimumab (human monoclonal antibody to TNF-α) + methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) significantly decreased several inflammatory biomarkers. Decreases in serum levels of serum amyloid A (SAA), E-selectin, and MMP-9 at wk 4 may be useful in predicting clinical response at wk 16.

Methods

Main objectives of this study were to:
- Assess the effect of golimumab + MTX on selected inflammatory biomarkers and
- Determine if these effects predict clinical response in RA
Sera from adults with active RA despite MTX therapy, who received:
- Subcutaneous injections of placebo + MTX (n=34) or
- Golimumab 50 or 100 mg every 2 or 4 wks + MTX (n=137)
  were analyzed for levels of CRP, SAA, IL-18, E-selectin, MMP-9 and TIMP-1

Results

Golimumab + MTX treatment decreased serum CRP, SAA, IL-18, E-selectin, TIMP-1, and MMP-9 levels vs MTX
This difference was noted first at wk 4; decreases were sustained through wk 16
Larger magnitudes of decrease in all biomarkers were observed for clinical responders vs nonresponders
Reductions in levels of SAA, E-selectin, MMP-9 at wk 4 correlated with improvement in swollen joint count (SJC) at wk 16
Same was true for reductions in E-selectin with improvement in tender joint count at wk 16
After accounting for the biomarkers, however, treatment group was no longer significant for SJC

<< Previous
Is screening for hepatitis B and hepatitis C useful in patients...

Next >>
Prospective study of neuropsychiatric events in systemic lupus...

Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia
Journal of Clinical Oncology, 11/09/09 Relevance Score: 71%

High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: A randomised phase 2 trial
The Lancet, 11/05/09 Relevance Score: 69%

Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia
Cancer, 10/26/09 Relevance Score: 68%

Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor [alpha] therapies: Does the risk change with the time since start of treatment?
Arthritis & Rheumatism, 11/05/09 Relevance Score: 67%

Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias
Cancer Chemotherapy and Pharmacology, 10/05/09 Relevance Score: 66%