Rheumatology Medical News about ankylosing spondylitis;extra-articular manifestations;rheumatology

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Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice
Rheumatology, 07/01/09

Elewaut D et al. – This review focuses on current progress in treatment options in ankylosing spondylitis (AS) with special emphasis on extra-articular features.

TNF inhibition has demonstrated effectiveness in the treatment of AS symptoms
However, the efficacy of anti-TNF agents varies in the treatment of extra-articular manifestations and comorbidities
Significant reductions in the incidence of flares of uveitis and IBD with infliximab and adalimumab (uveitis only) treatment have been shown, but not with etanercept
All 3 anti-TNF agents (infliximab, adalimumab, etanercept) have demonstrated efficacy in psoriasis (not associated with AS)
When evaluating as to which agent to use in the treatment of AS, an important consideration is the overall well-being of the patient
To date, infliximab appears to be the best studied agent with a wide spectrum of proven efficacy

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Evaluation of inflammation and oxidative stress in ankylosing spondylitis: a role for macrophage migration inhibitory factor
Modern Rheumatology, 10/05/09 Relevance Score: 69%

Erythrocyte sedimentation rate, CRP level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis
Arthritis Care and Research, 11/02/09 Relevance Score: 68%

Uncommon case of ankylosing spondylitis associated with spontaneous occurring hypoparathyroidism
Rheumatology International, 11/11/09 Relevance Score: 67%

Concomitant cervical and thoracic spinal fractures in ankylosing spondylitis: A case report and review of literature
Injury Extra, 11/05/09 Relevance Score: 67%

A 2-year comparative open label randomized study of efficacy and safety of etanercept and infliximab in patients with ankylosing spondylitis
Rheumatology International, 10/27/09 Relevance Score: 67%