Rheumatology

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Immunopathogenesis of spondyloarthritis: Which cells drive disease?
Arthritis Research & Therapy, 06/29/09

Melis L et al. – This review summarises recent progress in ourunderstanding of the immunopathogenesis of spondyloarthritides (SpA) with special emphasis on the cellular constituents considered to be responsible for the initiation and/or perpetuation of inflammation.

• There is ample evidence that bone marrow as well as stromal cells seem to be involved in SpA pathogenesis
• However, the interaction of these cell types remains to be established
• There are several arguments favouring a role for haematopoietic cells in thepathophysiology of spondyloarthritis, including:
  • HLA-B27-associated dendritic cell disturbances
  • HLA-B27 misfolding properties, and
  • T helper 17 cells
• In addition, recent studies have pointed toward a pivotal role for stromal cells
• A major challenge, however, remains to determine how recently identified genetic associations such as IL-23 receptor polymorphisms may influence cellular targets in spondyloarthritis

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An epidemiological survey of low back pain and axial spondyloarthritis in a Chinese Han population
Scandinavian Journal of Rheumatology , 11/24/09

Inflammatory bowel disease serologies in ankylosing spondylitis patients: A pilot study
Arthritis Research & Therapy, 11/24/09

An open-source, self-explanatory touch screen in routine care. Validity of filling in the Bath measures on Ankylosing Spondylitis Disease Activity Index, Function Index, the Health Assessment Questionnaire and Visual Analogue Scales in comparison with paper versions
Rheumatology, 11/23/09

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