Rheumatology Medical News about spondyloarthritis;immunopathogenesis

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Immunopathogenesis of spondyloarthritis: Which cells drive disease?
Arthritis Research & Therapy, 06/29/09

Melis L et al. – This review summarises recent progress in ourunderstanding of the immunopathogenesis of spondyloarthritides (SpA) with special emphasis on the cellular constituents considered to be responsible for the initiation and/or perpetuation of inflammation.

There is ample evidence that bone marrow as well as stromal cells seem to be involved in SpA pathogenesis
However, the interaction of these cell types remains to be established
There are several arguments favouring a role for haematopoietic cells in thepathophysiology of spondyloarthritis, including:
- HLA-B27-associated dendritic cell disturbances
- HLA-B27 misfolding properties, and
- T helper 17 cells
In addition, recent studies have pointed toward a pivotal role for stromal cells
A major challenge, however, remains to determine how recently identified genetic associations such as IL-23 receptor polymorphisms may influence cellular targets in spondyloarthritis

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Clinical assessment and outcome research in spondyloarthritis
Current Rheumatology Reports, 10/14/09 Relevance Score: 85%

An epidemiological survey of low back pain and axial spondyloarthritis in a Chinese Han population
Scandinavian Journal of Rheumatology, 11/24/09 Relevance Score: 84%

Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS), and clinical and magnetic resonance imaging measures of disease activity in a 1 year follow-up study of patients with axial spondyloarthritis treated with TNF-alpha inhibitors
Annals of Rheumatic Diseases, 10/01/09 Relevance Score: 80%