Rheumatology

Your Article Summary

See Latest Articles

Immunopathogenesis of spondyloarthritis: Which cells drive disease?
Arthritis Research & Therapy, 06/29/09

Melis L et al. – This review summarises recent progress in ourunderstanding of the immunopathogenesis of spondyloarthritides (SpA) with special emphasis on the cellular constituents considered to be responsible for the initiation and/or perpetuation of inflammation.

• There is ample evidence that bone marrow as well as stromal cells seem to be involved in SpA pathogenesis
• However, the interaction of these cell types remains to be established
• There are several arguments favouring a role for haematopoietic cells in thepathophysiology of spondyloarthritis, including:
  • HLA-B27-associated dendritic cell disturbances
  • HLA-B27 misfolding properties, and
  • T helper 17 cells
• In addition, recent studies have pointed toward a pivotal role for stromal cells
• A major challenge, however, remains to determine how recently identified genetic associations such as IL-23 receptor polymorphisms may influence cellular targets in spondyloarthritis

Today in Spondylarthropathies...keeping you current

Receive free subspecialty "5-minute updates" via email

Infliximab treatment in patients with rheumatoid arthritis and spondyloarthropathies in one rheumatological center: two years drug survival
Rheumatology International, 10/14/09

Erythrocyte sedimentation rate, CRP level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis
Arthritis Care and Research , 11/02/09

Recreational Exercise in Rheumatic Diseases
International Journal of Sports Medicine, 10/30/09

See All of Spondylarthropathies